A Guide to Self-Injecting Medications: Semaglutide, Tirzepatide, Insulin, and HCG Hormone


Self-injection of medications like semaglutides (Ozempic, Wegovy), tirzepatides (Mounjaro, Zepbound), insulin, and HCG hormone is a critical skill for managing various health conditions. This instructional discussion will cover essential aspects such as proper injection sites, safety measures, and choosing the right needle and syringe size for subcutaneous administration.

1. Understanding Subcutaneous Injection

Subcutaneous injections deliver medication into the fat layer beneath the skin. This method ensures the medication is absorbed slowly and consistently. It is commonly used for hormones like insulin and HCG, as well as for diabetes and weight loss medications like semaglutide and tirzepatide.

needle tract from sub cutaneous injection of ozempic/wegovy

Skin subcutaneous Injection diagram illustration

2. Choosing the Correct Needle and Syringe

Selecting the right needle and syringe is vital for effective and comfortable injections:

  • Needle Size: Typically, a 4-8 mm, 30-32 gauge needle is recommended for subcutaneous injections. The small diameter helps reduce discomfort.
  • Syringe Size: The syringe size depends on the dose of your medication. Common sizes range from 0.3 mL to 1 mL. Your healthcare provider will advise the best size based on your prescription.

3. Safe Injection Practices

Before injecting, ensure you:

  • Wash Hands: Always wash your hands thoroughly with soap and water.
  • Prepare Medication: Check the medication label, expiration date, and clarity. Do not use if cloudy or discolored unless specified by the medication guide.
  • Sanitize: Clean the injection site with an alcohol swab and let it air dry to minimize infection risk.

4. Best Injection Sites

Choosing an appropriate site is crucial for absorption and comfort:

  • Abdomen: The preferred site for many injections. Avoid the two-inch area around the navel. Use a different spot each time to prevent tissue hardening.
  • Thighs: The upper, outer area is ideal. This site is especially convenient for self-injectors.
  • Arms: The back of the upper arms can be used if you have assistance, as it might be hard to reach by yourself.


5. Performing the Injection

  • Step 1: Prepare the Injection Site. After sanitizing, let the area dry completely to avoid stinging.
  • Step 2: Pinch the Skin. Lightly pinch a 1-2 inch area of your skin to make a bulge. This technique ensures the needle penetrates the subcutaneous tissue rather than muscle.
  • Step 3: Insert the Needle. Hold the syringe like a pencil and insert the needle at a 45 to 90-degree angle with a swift, steady motion. The angle depends on your body size; thinner individuals might need a more acute angle.
  • Step 4: Inject the Medication. Once the needle is in place, release the pinched skin and press the plunger slowly and steadily until all the medication is injected.
  • Step 5: Withdraw the Needle. Pull the needle out quickly and apply gentle pressure with a cotton ball or gauze. Do not rub the area.

6. Post-Injection Care

  • Dispose of Needles Properly: Use a sharps container to dispose of needles and syringes. Do not reuse needles.
  • Monitor for Reactions: Check the injection site for excessive redness, swelling, or infection signs. Contact your healthcare provider if you experience unusual symptoms.


Self-injecting medication can seem daunting at first, but with proper technique and safety practices, it becomes manageable. Always follow your healthcare provider’s instructions and reach out to them with any concerns about your injection routine. This self-care procedure is empowering and critical for your treatment and well-being.